Loss of collagen and osteoarthritis, what are the links?

Collagen and osteoarthritis are two terms frequently mentioned together when it comes to joint health. Collagen, an essential protein in the human body, plays a crucial role in maintaining the structure and health of the joints. 

Osteoarthritis, for its part, is a degenerative joint disease that affects millions of people worldwide. 

This article explores in detail the links between collagen and osteoarthritis, the potential benefits of collagen dietary supplements for the joints, and how to choose the appropriate supplement to improve joint health. 

For those interested in natural solutions, marine collagen treatments and hydrolyzed marine collagen powders can offer significant benefits.

What is collagen and why is it essential for our joints?

Collagen is the most abundant structural protein in the human body, accounting for about 30% of total proteins. It is the main component of connective tissues, such as skin, tendons, ligaments, cartilage, and bones. 

It can be considered a kind of "biological glue" (the word collagen comes from the Greek kólla, meaning glue), ensuring the cohesion, elasticity, and strength of these structures.

At the joint level, type II collagen is predominantly present in hyaline cartilage, the soft tissue that covers the bone ends at the joints and allows smooth, frictionless movement. 

Collagen also contributes to the good mechanical resistance of ligaments and tendons. Without sufficient intake or quality endogenous production, these structures lose their elasticity, become fragile, and are more vulnerable to microtraumas.

Read also: benefits of collagen 

What is osteoarthritis and how does it develop?

Osteoarthritis is a chronic and degenerative joint disease characterized by progressive wear of the articular cartilage. The cartilage normally acts as a cushion between the bones, allowing smooth and pain-free movements. When the cartilage deteriorates, the bones can come into direct contact, causing pain, inflammation, stiffness, and loss of mobility.

The progression of osteoarthritis is multifactorial:

• The natural aging is the main cause.

• Overweight increases the mechanical pressure on weight-bearing joints such as the knees and hips.

• Joint injuries, intensive sports activities, or conversely, sedentary lifestyle, can also be responsible.

• Finally, genetic and hormonal factors influence the quality of cartilage and the rate of degradation.

Osteoarthritis mainly affects people over 50 years old, but can occur earlier, especially in cases of predisposition.

What is the link between collagen loss and the onset of osteoarthritis?

Natural collagen synthesis decreases from the age of 25, and this decline accelerates over time. This phenomenon has a direct impact on joint health. Indeed, cartilage is composed of more than 60% type II collagen, which gives it its resistance to pressure and its flexibility.

When this production weakens:

• The cartilage becomes more fragile, thinner, less elastic.

• Joints lose their ability to absorb shocks.

• The connective tissue deteriorates, causing inflammations, bone friction, and chronic pain.

This collagen deficiency thus contributes to the progressive degradation of cartilage, a key mechanism in the development of osteoarthritis. It is therefore essential to support collagen production or provide it through quality dietary supplements to preserve joint function, slow the progression of the condition, and improve quality of life.

To learn more, check out our dedicated guide benefits of collagen on joints and discover how targeted active ingredients can truly relieve joint pain.

The role of collagen in maintaining cartilage and connective tissues

Collagen, particularly type II, is one of the main components of articular cartilage. It acts as a natural framework that provides connective tissues with strength, flexibility, and resistance to compression. Also present in tendons and ligaments, it ensures the structural cohesion of the entire joint apparatus.

With age or under the effect of aggravating factors (chronic inflammations, oxidative stress, nutritional deficiencies...), collagen synthesis decreases, making the joints more vulnerable to friction, pain, and degeneration.

The intake of hydrolyzed collagen-based dietary supplements can help to support cartilage structure, limit degenerative processes, and preserve joint mobility. Several studies show that this supplementation contributes to reducing joint sensitivity, while improving the quality of life of people suffering from osteoarthritis.

How can collagen help relieve pain related to osteoarthritis?

Joint pain related to osteoarthritis mainly results from cartilage degradation, local inflammation, and sometimes bone microtraumas caused by bone-on-bone friction. Hydrolyzed collagen acts on several levels to relieve this pain:

• It stimulates the endogenous production of collagen by chondrocytes (cartilage cells), thereby strengthening the structure of the cartilage tissue.

• It helps to reduce inflammation by modulating certain pro-inflammatory cytokines involved in osteoarthritis.

• It promotes better joint lubrication by strengthening the extracellular matrix that traps hyaluronic acid and hydrophilic molecules.

• It improves joint mobility and reduces the sensation of stiffness, especially in the knees and hips.

The benefits of collagen in relieving arthritic pain are now supported by several clinical studies, with significant results from 8 to 12 weeks of continuous supplementation.

Can cartilage really be regenerated with collagen?

The complete regeneration of articular cartilage remains a biological challenge, as this tissue is poorly vascularized and has low renewal capacity. However, several scientific studies suggest that hydrolyzed collagen can stimulate partial repair processes, notably by:

• Activating the proliferation of chondrocytes ;

• Promoting the synthesis of the extracellular matrix ;

• Reducing the activity of enzymes responsible for cartilage degradation, such as metalloproteinases.

Thus, even though collagen does not allow for complete regeneration of worn cartilage, it actively contributes to its stabilization, protection, and functional repair, thereby limiting the progression of the disease and the associated pain.

To learn more, discover the benefits of collagen on muscles.

Can collagen prevent or slow the progression of osteoarthritis?

As a preventive measure, regular intake of hydrolyzed collagen can play a fundamental role in strengthening joint tissues and maintaining cartilage integrity, especially in at-risk individuals:

• sportsmen,

• elderly people,

• overweight individuals,

• or in case of a family history of osteoarthritis.

In addition to an anti-inflammatory diet, an active lifestyle, and specific micronutrients (vitamin C, MSM, hyaluronic acid…), collagen can slow down the degenerative process, delay the onset of symptoms, and relieve chronic pain.

Collagen supplementation does not replace medical treatment, but serves as a scientifically recognized natural support for joint health.

Differences between marine, bovine, hydrolyzed collagen...

The collagen used in supplementation can come from different sources, the most common being marine collagen, bovine collagen, and hydrolyzed collagen. Each has interesting characteristics depending on the targeted needs.

• Marine collagen, extracted from fish skin or bones, is rich in type I collagen, and sometimes type III. It is particularly valued for its fine structure, purity, and high bioavailability, which means it is better absorbed and more quickly utilized by the body.

• Bovine collagen, derived from beef bones and cartilage, mainly contains type I and III collagen. It is also effective, but often less absorbable than marine collagen.

• Hydrolyzed collagen, for its part, refers to collagen that has been enzymatically cut into small peptides, called collagen oligopeptides. This "predigested" form facilitates intestinal passage and maximizes absorption.

The best collagen for joints is generally a hydrolyzed marine collagen, as it combines the benefits of purity, high absorption, and an amino acid profile close to that of human collagen.

To make the right choice, discover which collagen to choose based on your needs.

The criteria for choosing the right supplement

To be truly effective, a collagen-based supplement must meet several key requirements:

• Origin and traceability: Favor sustainable sources, free from heavy metal residues and chemical solvents, with quality certifications (HACCP, ISO, etc.).

• Type of collagen: For joints, type II (found in cartilage) is recommended, but for overall action (cartilage, tendons, bones), types I and III are also essential.

• Bioavailability: Prefer hydrolyzed collagens, whose molecular weight is less than 2000 Da, for optimal absorption.

• Synergistic formula: The presence of anti-inflammatory, antioxidant, or remineralizing active ingredients enhances the effectiveness of collagen on the joint area.

• Absence of controversial additives: Choose formulas without added sugars, without GMOs, without nanoparticles, and without unnecessary excipients.

Why marine collagen is the best natural option

The hydrolyzed marine collagen is distinguished by its fine and homogeneous structure, which promotes rapid absorption at the intestinal level, thus allowing a targeted and effective action on the joints.

It mainly contains type I collagen, the most abundant in the human body, and particularly involved in the maintenance of cartilage, tendons, and ligaments. Thanks to its structure similar to human collagen, it is ideal for people suffering from osteoarthritis, joint stiffness, or for prevention of mechanical pain.

Its marine origin (derived from fish skin or bones) also makes it a cleaner option and often better tolerated than bovine or porcine sources.

To learn more about the benefits of collagen on bone health, check out our dedicated article.

Product focus: D-LAB's Pro-Collagen Flexibility

The Pro-Collagen Flexibility is an expert formula, an excellent option for collagen for osteoarthritis, designed to meet the needs of people suffering from joint pain, stiffness, or wishing to preserve the flexibility of their joints with age or physical activity.

✨ Here is what makes it unique and effective:

• Hydrolyzed type I & III collagen peptides, ultra-assimilable, derived from marine sources, which act directly on the structure of cartilage, tendons, and ligaments, while stimulating the natural production of collagen by the body.

• A powerful plant synergy:

  • Titrated ash extract, known for its natural anti-inflammatory properties, useful for limiting mechanical pain;

  • Blackcurrant with antioxidant and anti-inflammatory properties, which supports circulation and reduces the sensation of heavy legs;

  • Devil's claw, a plant traditionally used to relieve chronic joint pain and improve mobility ;

  • Patented scented verbena, with calming and draining effects, ideal for stiff and sensitive joints.

• A complex without compromise: without animal gelatin, without preservatives, without colorants, made in France according to strict standards.

The Pro-Collagen Flexibility is therefore a natural, complete, and highly functional solution, designed to deeply support joint structure, reduce chronic discomfort, and slow down the effects of joint aging, especially in cases of early or moderate osteoarthritis.

Research results on pain relief and cartilage regeneration

Numerous clinical studies have proven that collagen supplementation can alleviate joint pain and promote cartilage regeneration. For example, research published in the journal "Osteoarthritis and Cartilage" demonstrated that participants who consumed hydrolyzed collagen experienced a significant reduction in joint pain compared to those who took a placebo.

Comparison with other methods (anti-inflammatories, chondroprotectors…)

Collagen-based dietary supplements are a natural alternative to anti-inflammatory drugs and chondroprotectors. Unlike anti-inflammatory drugs, which temporarily relieve pain, collagen acts on the underlying causes by strengthening the cartilage. Chondroprotectors, such as glucosamine and chondroitin, are often used in addition to collagen for synergistic effects.

Scientific recommendations

Researchers recommend regular collagen consumption to preserve joint health. A collagen treatment of at least three months is advised to achieve visible results. It is also recommended to combine collagen with other essential nutrients such as vitamin C, which plays a crucial role in collagen synthesis.

To learn more about the benefits of collagen, check out our dedicated article.

Dosage, duration of treatment, and key times to take it

Collagen supplementation is all the more effective when it is well dosed, regular, and sustained. According to scientific literature, a daily dose of 2 to 10 grams of hydrolyzed collagen effectively supports joint health, especially in people suffering from pain, stiffness, or osteoarthritis.

At D-LAB NUTRICOSMETICS, formulations are designed according to the most recent clinical studies, and recommend a daily intake of 5 grams of hydrolyzed collagen peptides, an optimal amount for visible and measurable results on joint health.

💡Recommended treatment duration: between 3 and 6 months minimum, to allow the body time to repair, strengthen, and stabilize its connective tissues. Effects can be felt as early as 6 to 8 weeks, including a reduction in pain and improved joint mobility, as demonstrated by several clinical trials.

⏰ Time of intake :
Collagen can be taken at any time of the day, with or without meals. However, some studies suggest that consuming it in the evening, before bedtime, could promote nighttime tissue regeneration, when the body is most active at the cellular level.

Food synergies: what to combine with collagen?

Endogenous collagen production does not depend solely on peptide intake. It relies on the activation of specific enzymatic pathways, which require certain nutritional cofactors:

• Vitamin C: essential for the hydroxylation of amino acids constituting collagen, it naturally stimulates synthesis and stabilizes the formed fibers.

• Antioxidants: found in berries, green vegetables, green tea, or raw cocoa, they protect collagen against free radicals responsible for its degradation.

• Quality proteins (eggs, legumes, quinoa): they provide the amino acids necessary for the synthesis of structural proteins, including collagen.

• Hyaluronic acid, MSM, zinc, silicon: these active ingredients strengthen the structure of joint tissues, work in synergy with collagen, and contribute to joint flexibility.

D-LAB products to combine for a strengthened effect

To enhance the effectiveness of collagen supplementation and sustainably protect the joints, D-LAB NUTRICOSMETICS offers expert, ultra-targeted formulas with patented and clinically tested active ingredients.

✨ To include in a complete joint routine:

Collagen Absolute – Tablets

This ultra-concentrated formula combines hydrolyzed marine collagen + elastin, in the same proportions as those of human skin, thanks to the patented complex COLLACTIVE™.

These tablets:

• Stimulate endogenous collagen synthesis,

• Contributing to strengthening the skin and connective tissue,

• Also support joint and tissue density.
  Recommended dosage: 2 to 4 tablets per day, ideally in the morning, in a 3-month course for lasting results.

Collagen Absolute – Shots

Same formula, new format: these ready-to-drink shots concentrate the COLLACTIVE™ complex, combining hydrolyzed marine collagen + elastin in biomimetic proportions.

This liquid format is perfect for:

• A rapid assimilation ,

• A quick routine without constraints,

• Visible results on the flexibility of fabrics.
  1 shot per day, pure or diluted, in a renewable 28-day treatment.

This duo of formats – tablets and shots – allows everyone to customize their routine according to their habits, while benefiting from the proven effectiveness of an active ingredient clinically tested to improve the elasticity, density, and quality of connective tissues.

Practical tips for easy daily integration

• Collagen powder is the most versatile form:

  • It easily blends into a smoothie, a plant-based yogurt, a soup, or even in a coffee (neutral taste).

  • It can be included in breakfast, or in a post-workout snack to promote joint recovery.

• For intermittent fasting enthusiasts, it is recommended to consume collagen during the feeding window, ideally combined with a source of vitamin C or a fresh fruit (kiwi, orange, berries, lemon).
• Regular intake, at the same time each day, optimizes cellular receptivity and promotes lasting effects.

Summary of the benefits of collagen for osteoarthritis

Collagen is fundamental for joint health. It helps preserve the structure and function of cartilage, alleviates joint pain, and could potentially slow the progression of osteoarthritis. Collagen supplementation offers a natural and effective solution to optimize joint health and prevent pain associated with osteoarthritis.

Final tips to naturally soothe joint pain

In addition to collagen supplementation, it is essential to maintain a healthy lifestyle, including a balanced diet rich in essential nutrients, regular physical activity, and maintaining an ideal weight. These measures, combined with collagen supplements, can help relieve joint pain and improve quality of life.

Scientific studies

• Clark KL, Sebastianelli W, Flechsenhar KR, et al. "24-week study on the use of collagen hydrolysate as a dietary supplement in athletes suffering from activity-related joint pain." Curr Med Res Opin. 2008.
• Oesser S, Adam M, Babel W, et al. "Oral administration of 14C-labeled gelatin hydrolysate leads to accumulation of radioactivity in the cartilage of mice." J Nutr. 1999.
• Shaw G, Lee-Barthel A, Ross ML, et al. "Vitamin C-enriched gelatin supplementation before intermittent activity increases collagen synthesis." Am J Clin Nutr. 2017.