Loss of collagen and osteoarthritis, what are the links?

Collagen and osteoarthritis are two terms frequently mentioned together when it comes to joint health. Collagen, an essential protein in the human body, plays a crucial role in maintaining the structure and health of the joints. 

Osteoarthritis, on the other hand, is a degenerative joint disease that affects millions of people around the world. 

This article explores in detail the links between collagen and osteoarthritis, the potential benefits of collagen dietary supplements for the joints, and how to choose the appropriate supplement to improve joint health. 

For those who are interested in natural solutions, the marine collagen cures and hydrolyzed marine collagen powders can offer significant benefits.

What is collagen and why is it essential for our joints?

Collagen is the most abundant structural protein in the human body, accounting for about 30% of total proteins. It is the main component of connective tissues, such as skin, tendons, ligaments, cartilage, and bones. 

"It can be considered a kind of 'biological glue' (the word collagen comes from the Greek kólla, meaning glue), ensuring the cohesion, elasticity, and strength of these structures."

At the joint level, type II collagen is predominantly present in hyaline cartilage, this soft tissue that covers the bony ends at the joints and allows for smooth, frictionless movement. 

Collagen also contributes to the good mechanical resistance of ligaments and tendons. Without sufficient intake or quality endogenous production, these structures lose their elasticity, become fragile, and are more vulnerable to microtraumas.

Read also: benefits of collagen 

What is osteoarthritis and how does it develop?

Osteoarthritis is a chronic and degenerative joint disease characterized by a progressive wear of the articular cartilage. The latter normally acts as a cushion between the bones, allowing for smooth and pain-free movements. When the cartilage deteriorates, the bones can come into direct contact, causing pain, inflammation, stiffness, and loss of mobility.

The progression of osteoarthritis is multifactorial:

• Natural aging is the main cause.

• Being overweight increases the mechanical pressure on weight-bearing joints such as the knees and hips.

• Joint traumas, intensive sports activities, or conversely sedentary lifestyle, can also be responsible for this.

• Finally, genetic and hormonal factors influence the quality of cartilage and the rate of degradation.

Osteoarthritis mainly affects people over 50, but can occur earlier, especially in cases of predisposition.

What is the link between collagen loss and the onset of osteoarthritis?

The natural synthesis of collagen decreases from the age of 25, and this decline accelerates over time. This phenomenon has a direct impact on joint health. Indeed, cartilage is composed of more than 60% type II collagen, which gives it its resistance to pressure and flexibility.

When this production weakens:

• The cartilage becomes more fragile, thinner, less elastic.

• The joints lose their ability to absorb shocks.

• The connective tissue deteriorates, leading to inflammations, bone friction, and chronic pain.

This collagen deficit thus contributes to the progressive degradation of cartilage, a key mechanism in the development of osteoarthritis. It is therefore essential to support collagen production or to provide it through quality dietary supplements to preserve joint function, slow the progression of the disease, and improve quality of life.

To go further, consult our dedicated guide benefits of collagen on joints and discover how targeted ingredients can truly relieve joint pain.

The role of collagen in the maintenance of cartilage and connective tissues

Collagen, particularly type II, is one of the main components of articular cartilage. It acts as a natural framework that provides connective tissues with strength, flexibility, and resistance to compression. Also present in tendons and ligaments, it ensures the structural cohesion of the entire joint apparatus.

With age or under the influence of aggravating factors (chronic inflammation, oxidative stress, nutritional deficiencies...), collagen synthesis decreases, making the joints more vulnerable to friction, pain, and degeneration.

The intake of hydrolyzed collagen dietary supplements can help support the structure of cartilage, limit degenerative processes, and preserve joint mobility. Several studies show that this supplementation contributes to reducing joint sensitivity, while improving the quality of life for people suffering from osteoarthritis.

How can collagen help relieve pain related to osteoarthritis?

Joint pain related to osteoarthritis primarily results from cartilage degradation, local inflammation, and sometimes from bone microtraumas induced by bone-on-bone friction. Hydrolyzed collagen acts at several levels to relieve this pain:

• It stimulates the endogenous production of collagen by chondrocytes (cartilage cells), thereby strengthening the structure of the cartilage tissue.

• It helps to reduce inflammation by modulating certain pro-inflammatory cytokines involved in osteoarthritis.

• It promotes better joint lubrication by strengthening the extracellular matrix that traps hyaluronic acid and hydrophilic molecules.

• It improves joint mobility and reduces the feeling of stiffness, particularly in the knees and hips.

The benefits of collagen in relieving arthritic pain are now supported by several clinical studies, with significant results observed after 8 to 12 weeks of continuous supplementation.

Can we really regenerate cartilage with collagen?

Complete regeneration of articular cartilage remains a biological challenge, as this tissue is poorly vascularized and weakly renewable. However, several scientific studies suggest that hydrolyzed collagen may stimulate partial repair processes, particularly by:

• Activating the proliferation of chondrocytes ;

• Promoting the synthesis of the extracellular matrix ;

• Reducing the activity of the enzymes responsible for cartilage degradation, such as metalloproteinases.

Thus, even if collagen does not allow for a complete regeneration of worn cartilage, it actively contributes to its stabilization, protection, and functional repair, thereby limiting the progression of the disease and the associated pain.

To learn more, discover the benefits of collagen on muscles.

Can collagen prevent or slow the progression of osteoarthritis?

As a preventive measure, a regular intake of hydrolyzed collagen can play a fundamental role in maintaining the integrity of cartilage, especially in at-risk individuals:

• sportsmen,

• elderly people,

• overweight individuals,

• or in case of a family history of osteoarthritis.

In addition to an anti-inflammatory diet, an active lifestyle, and specific micronutrients (vitamin C, MSM, hyaluronic acid…), collagen can therefore slow down the degenerative process, delay the onset of symptoms, and relieve chronic pain.

'Collagen supplementation does not replace medical treatment, but it is a scientifically recognized natural support for joint health.'

Differences between marine collagen, bovine, hydrolyzed...

The collagen used in supplementation can come from different sources, the most common being marine collagen, bovine collagen, and hydrolyzed collagen. Each has interesting characteristics depending on the targeted needs.

• Marine collagen, extracted from the skin or bones of fish, is rich in type I collagen, and sometimes III. It is particularly valued for its fine structure, purity, and high bioavailability, which means it is better absorbed and more quickly utilized by the body.

• Bovine collagen, derived from beef bones and cartilage, mainly contains types I and III collagen. It is also effective, but often less absorbable than marine collagen.

• Hydrolyzed collagen, for its part, refers to collagen that has been enzymatically cut into small peptides, called collagen oligopeptides. This "predigested" form facilitates intestinal passage and maximizes absorption.

The best collagen for joints is generally a marine-derived hydrolyzed collagen, as it combines the benefits of purity, high absorption, and an amino acid profile similar to that of human collagen.

To make the right choice, find out which collagen to choose based on your needs.

The criteria for choosing the right supplement

To be truly effective, a collagen-based supplement must meet several key requirements:

• Origin and traceability: Prefer sustainable sources, free from heavy metal residues and chemical solvents, with quality certifications (HACCP, ISO, etc.).

• Type of collagen: For joints, type II (found in cartilage) is recommended, but for overall action (cartilage, tendons, bones), types I and III are also essential.

• Bioavailability: Prefer hydrolyzed collagens, with a molecular weight of less than 2000 Da, for optimal absorption.

• Synergistic formula: The presence of anti-inflammatory, antioxidant, or remineralizing active ingredients enhances the effectiveness of collagen on the joint sphere.

• Absence of controversial additives: Choose formulas without added sugars, without GMOs, without nanoparticles, and without unnecessary excipients.

Why marine collagen is the best natural option

Hydrolyzed marine collagen stands out for its fine and homogeneous structure, which promotes rapid absorption at the intestinal level, thus allowing for a targeted and effective action on the joints.

It mainly contains type I collagen, the most abundant in the human body, and particularly involved in the maintenance of cartilage, tendons, and ligaments. Thanks to its structure similar to human collagen, it is ideal for people suffering from osteoarthritis, joint stiffness, or for preventing mechanical pain.

Its marine origin (derived from fish skin or bones) also makes it a cleaner option and often better tolerated than bovine or porcine sources.

To learn more about the benefits of collagen on bone health, check out our dedicated article.

Product focus: The Pro-Collagen Flexibility by D-LAB

The Pro-Collagen Flexibility is an expert formula, an excellent option for collagen for osteoarthritis, designed to meet the needs of individuals suffering from joint pain, stiffness, or wishing to maintain the flexibility of their joints with age or physical activity.

✨ Here is what makes it unique and effective:

• Hydrolyzed collagen peptides type I & III, ultra-absorbable, derived from marine sources, that act directly on the structure of cartilage, tendons, and ligaments, while stimulating the natural production of collagen by the body.

• A powerful plant synergy:

  • Extract of title ash, recognized for its natural anti-inflammatory properties, useful for limiting mechanical pain;

  • Cassis with antioxidant and anti-inflammatory properties, which supports circulation and reduces the feeling of heavy legs;

  • Devil's claw, a plant traditionally used to relieve chronic joint pain and improve mobility;

  • Patented scented verbena, with calming and draining effects, ideal for stiff and sensitive joints.

• A complex without compromise: without animal gelatin, without preservatives, without colorants, made in France according to strict standards.

The Pro-Collagen Flexibility is therefore a natural, complete, and highly functional solution designed to support the joint structure deeply, reduce chronic discomfort, and slow down the effects of joint aging, particularly in cases of early or moderate osteoarthritis.

Results of research on pain relief and cartilage regeneration

Numerous clinical studies have proven that collagen supplementation can alleviate joint pain and promote cartilage regeneration. For example, research published in the journal "Osteoarthritis and Cartilage" demonstrated that participants who consumed hydrolyzed collagen experienced a significant reduction in joint pain compared to those who took a placebo.

Comparison with other methods (anti-inflammatory, chondroprotective…)

Collagen-based dietary supplements are a natural alternative to anti-inflammatories and chondroprotectors. Unlike anti-inflammatories, which temporarily soothe pain, collagen addresses the underlying causes by strengthening cartilage. Chondroprotectors, such as glucosamine and chondroitin, are often used in conjunction with collagen for synergistic effects.

Scientific Recommendations

Researchers recommend regular collagen consumption to maintain joint health. A collagen treatment of at least three months is advised to achieve visible results. It is also recommended to combine collagen with other essential nutrients such as vitamin C, which plays a crucial role in collagen synthesis.

To learn more about the benefits of collagen, check out our dedicated article.

Dosage, duration of treatment and key moments for consumption

Collagen supplementation is all the more effective when it is well-dosed, regular, and sustainable. According to scientific literature, a daily dose of 2 to 10 grams of hydrolyzed collagen effectively supports joint health, especially in individuals suffering from pain, stiffness, or osteoarthritis.

At D-LAB NUTRICOSMETICS, the formulations are designed according to the latest clinical studies, and recommend a daily intake of 5 grams of hydrolyzed collagen peptides, an optimal amount for visible and measurable results on joint health.

💡Recommended duration of treatment: between 3 and 6 months minimum, to give the body time to repair, strengthen, and stabilize its connective tissues. Effects may be felt as early as 6 to 8 weeks, including a reduction in pain and improved joint mobility, as demonstrated by several clinical trials.

⏰ Moment of capture :
Collagen can be taken at any time of the day, with or without meals. However, some studies suggest that consuming it in the evening, before bedtime, could promote nighttime tissue regeneration, a time when the body is most active at the cellular level.

Food synergies: what to combine with collagen?

The endogenous production of collagen does not solely depend on the intake of peptides. It relies on the activation of specific enzymatic pathways, which require certain nutritional cofactors:

• Vitamin C: essential for the hydroxylation of the amino acids that make up collagen, it naturally stimulates synthesis and stabilizes the formed fibers.

• Antioxidants: found in berries, green vegetables, green tea, or raw cocoa, they protect collagen against free radicals responsible for its degradation.

• Quality proteins (eggs, legumes, quinoa): they provide the amino acids necessary for the synthesis of structural proteins, including collagen.

• Hyaluronic acid, MSM, zinc, silicon: these active ingredients strengthen the structure of joint tissues, work in synergy with collagen, and contribute to joint flexibility.

D-LAB products to combine for an enhanced effect

To enhance the effectiveness of collagen supplementation and sustainably protect the joints, D-LAB NUTRICOSMETICS offers expert, ultra-targeted formulas with patented and clinically tested active ingredients.

✨ To be integrated into a complete joint routine:

Collagen Absolute – Tablets

This ultra-concentrated formula combines hydrolyzed marine collagen + elastin, in the same proportions as those found in human skin, thanks to the patented complex COLLACTIVE™.

These tablets:

• Stimulating the synthesis of endogenous collagen,

• Contributes to strengthening the skin and connective structure,

• Also support the joint and tissue density.
  Recommended dosage: 2 to 4 tablets per day, ideally in the morning, for a course of 3 months for lasting results.

Collagen Absolute – Shots

Same formula, new format: these ready-to-drink shots concentrate the COLLACTIVE™ complex, combining hydrolyzed marine collagen + elastin in biomimetic proportions.

This liquid format is perfect for:

• A rapid assimilation,

• An express routine without constraints,

• Visible results on the flexibility of tissues.
  1 shot per day, pure or diluted, in a 28-day renewable course.

This duo of formats – tablets and shots – allows everyone to personalize their routine according to their habits, while benefiting from the proven effectiveness of an clinically tested active ingredient to improve elasticity, density, and quality of connective tissues.

Practical tips for easy daily integration

• The powdered collagen is the most versatile form:

  • It mixes easily into a smoothie, a plant-based yogurt, a soup, or even in a coffee (neutral taste).

  • It can be integrated into breakfast, or in a post-workout snack to promote joint recovery.

• For fans of intermittent fasting, it is recommended to consume collagen during the eating window, ideally paired with a source of vitamin C or a fresh fruit (kiwi, orange, berries, lemon).
• Regular intake, at the same time every day, optimizes cellular receptivity and promotes lasting effects.

Summary of the benefits of collagen for osteoarthritis

Collagen is fundamental for joint health. It helps preserve the structure and function of cartilage, alleviates joint pain, and could potentially slow the progression of osteoarthritis. Collagen supplementation offers a natural and effective solution to optimize joint health and prevent pain associated with osteoarthritis.

Final tips for naturally soothing joint pain

In addition to collagen supplementation, it is essential to maintain a healthy lifestyle, including a balanced diet rich in essential nutrients, regular physical activity, and maintaining an ideal weight. These measures, combined with collagen supplements, can help relieve joint pain and improve quality of life.

Scientific Studies

• Clark KL, Sebastianelli W, Flechsenhar KR, et al. "24-week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain." Curr Med Res Opin. 2008.
• Oesser S, Adam M, Babel W, et al. "Oral administration of 14C-labeled gelatin hydrolysate leads to an accumulation of radioactivity in the cartilage of mice." J Nutr. 1999.
• Shaw G, Lee-Barthel A, Ross ML, et al. "Supplementation with vitamin C-enriched gelatin before intermittent activity increases collagen synthesis." Am J Clin Nutr. 2017.