Hydrolyzed collagen: benefits, effectiveness, and tips for choosing

Hydrolyzed collagen is now established as an essential dietary supplement for all those who wish to improve the health of their skin, joints, hair, and nails. 

Thanks to its low molecular weight, it offers exceptional bioavailability, which means it is quickly absorbed and efficiently used by the body.

Derived from an enzymatic process called hydrolysis, this "predigested" collagen is scientifically recognized for its multiple benefits. It is a natural solution to preserve youthful skin, strengthen joint strength, and support the overall vitality of connective tissues.

✨ Discover our selection of collagen dietary supplements and collagen powders hydrolyzed formulated for optimal absorption and visible results.

What is hydrolysis?

Collagen is a major structural protein, representing about 30% of the body's total proteins. It ensures the cohesion, strength, and elasticity of tissues such as skin, bones, tendons, ligaments, hair, and nails.

Hydrolyzed collagen, also called collagen peptides, results from a process called enzymatic hydrolysis. This technique involves cutting the long collagen chains into smaller peptides, which are much more easily absorbed by the body.

How does the hydrolysis process work?

Hydrolysis is carried out by specific enzymes that break the peptide bonds of native collagen, thus reducing its average molecular weight to around 2,000 Da (Daltons). This reduced size allows the peptides to be more quickly absorbed by the intestine and to circulate in the body to act directly at the target tissues.

Differences between native and hydrolyzed

Native collagen, in its raw form, is a large molecule that is difficult to digest and poorly absorbed. In contrast, hydrolyzed collagen comes in the form of short peptides, highly digestible and scientifically validated for their effects on skin, joints, and hair.

To learn more, see our article on what collagen is.

Type I, II, and III collagen: what are the differences?

Collagen comes in several types, each having a specific function:

• Type I: the most abundant, present in skin, bones, tendons. It is responsible for firmness, density, and skin resistance.

• Type II: located in cartilage, it plays a central role in joint health.

• Type III: present in blood vessels, muscles, and organs, often in synergy with type I, it contributes to tissue elasticity.

Hydrolyzed type I collagen is the most used in nutricosmetics for its effects on skin, hair, and nails, while type II is targeted for joint comfort.

Marine, bovine, porcine collagen... which one to choose?

The choice of source depends on your goals and preferences:

• Hydrolyzed marine collagen: extracted from fish skin or bones, it offers excellent bioavailability and a structure close to human collagen. It is the ideal choice for skin beauty.

• Bovine collagen: derived from beef cartilage, it is rich in type I and III. Recommended for joints and skin.

• Porcine collagen: composition similar to human collagen, often used in mixed formulas.

For optimal effectiveness and high tolerance, hydrolyzed marine collagen remains the premium reference. Discover which collagen to choose.

Focus on the hydrolyzed marine form

Hydrolyzed marine collagen comes from fish sourced sustainably and is processed by gentle enzymatic hydrolysis. It is rich in specific amino acids like glycine, proline, and hydroxyproline, essential for endogenous collagen synthesis.

✔️ Its clinically proven benefits:

• Improvement of skin firmness and elasticity,

• Reduction of wrinkles and fine lines,

• Strengthening of nail and hair solidity,

• Support for joint flexibility.

To learn more about the visible effects of collagen, see our article: why take collagen?

Collagens based on Collactive™ – Overall beauty & skin firmness

The patented Collactive™ complex combines hydrolyzed marine collagen and elastin, in the same proportions as in human skin. It works synergistically to stimulate natural collagen synthesis, firm tissues, and smooth wrinkles. Ideal for firmness, elasticity, and prevention of skin aging.

✅ Selection of products based on Collactive™:

• Absolu de Collagène (tablets or shots)
  • Concentrated treatment for skin firmness, dermal density, and wrinkle reduction. -19% wrinkles in 28 days proven by clinical study.
  • Choice of format: tablets for an easy routine, or liquid shots for express absorption.
• Pro-Collagen New Skin Raspberry 
  • Expert anti-aging formula with Collactive™ + natural Vitamin C + hyaluronic acid + antioxidants.
  • Action on skin quality, protection against oxidative stress, and stimulation of endogenous collagen.
• Pro-Collagen Slimming Kiwi 
  • Caffeine-free version, formulated with melon SOD, mate, for a draining and firming effect.
  • Perfect for skin prone to water retention or cellulite.

Naticol®-based collagens – Targeted specialties (hair, spots, menopause)

Naticol® is a highly pure hydrolyzed marine collagen, known for its exceptional bioavailability and specific effects on the dermal and hair structure. It is ideal in targeted formulas with complementary active ingredients according to physiological needs.

✅ Selection of products based on Naticol®:

• Pro-Collagen Hair 360 
  • Unique synergy between Naticol® collagen, plant keratin, zinc, and arugula.
  • Promotes hair growth, fiber strengthening, and acts on the scalp structure.
• Pro-Collagen Menopause 
  • Specially formulated for the perimenopause and menopause period.
  • Helps to compensate for hormonal decline, preserve connective tissues, and support bone density.
• Pro-Collagen Anti-Spots
  • Anti-spot complex combining Naticol®, Belight®, rose petal extract.
  • Corrects pigmentation irregularities, evens out skin tone, and improves skin clarity.

Why choose D-LAB collagens?

• Patented and clinically tested collagens (Collactive™ & Naticol®)

• Sustainable marine origin, without GMOs or controversial additives

• Synergistic formulas, enriched with vitamin C, antioxidants, plants, or micronutrients

• Made in France, with a unique formulation requirement, manufactured in our own green factory in Auvergne.

Improvement of elasticity and firmness

Hydrolyzed collagen stimulates the natural production of new collagen and elastin fibers, two key components of the dermal structure. This stimulation helps to firm the skin, preserve its suppleness, and maintain a youthful and toned appearance. Thanks to its high bioavailability, hydrolyzed collagen works deeply where the skin needs it most.

Reduction of wrinkles and skin aging

The natural aging process causes a gradual decrease in collagen levels in the dermis, which promotes the appearance of winkles, fine lines, and skin sagging. Hydrolyzed collagen promotes cellular regeneration and increases the density of the dermal matrix, thus helping to smooth existing wrinkles and slow down skin aging.

Effect on hydration and cell regeneration

By strengthening the skin barrier and increasing the skin's ability to retain water, hydrolyzed collagen contributes to better hydration. It also plays an essential role in regeneration of epidermal cells, which promotes healthier, more radiant skin that is more resistant to external aggressions.

To learn more, see our article on drinkable collagen.

Support for cartilage and connective tissues

Collagen is a central component of articular cartilage. By providing the peptides necessary for its regeneration, hydrolyzed collagen helps to strengthen joint structures, improve flexibility, and limit wear related to age or physical activity.

For more information, see our blog on collagen and joints.

Pain reduction and mobility improvement

Thanks to its indirect anti-inflammatory action and its role in tissue repair, hydrolyzed collagen helps to relieve joint pain, especially in cases of osteoarthritis, and to restore better daily mobility.

Bone regeneration and osteoarthritis prevention

In synergy with calcium, vitamin D, and vitamin C, hydrolyzed collagen stimulates the activity of osteoblasts (cells responsible for bone formation) and preserves bone mineral density, thus helping to prevent osteoporosis and the progression of osteoarthritis.

Quality, traceability, and origin

Good collagen starts with a quality raw material, sourced from sustainable, traceable, and ideally marine sources. Hydrolyzed marine collagen, derived from wild fish, is now recognized as the purest and best absorbed form.

Molecular weight, bioavailability, and absorption

The low molecular weight of collagen peptides (ideally < 2,000 Da) is a key factor for optimal intestinal absorption. The smaller the peptides, the more quickly they are available to nourish the skin, joints, bones, and hair.

Purity criteria and absence of additives

Choose formulas non-GMO, free from controversial additives, no added sugars, and ideally clinically tested. At D-LAB NUTRICOSMETICS, collagen-based products meet these demanding standards for visible and lasting results.

Available formats: powder, capsules, liquid...

Hydrolyzed collagen comes in several formats:

• Capsules / tablets: convenient for a hassle-free routine;

• Liquid shots: fast absorption, portable format;

• Powders: to be diluted in drinks or recipes for an enjoyable course.

Dosage and ideal timing for intake

For optimal effectiveness, it is recommended to consume between 2 and 10g of hydrolyzed collagen per day, fasting in the morning or in the evening before bed. A minimum 3-month course is generally necessary to see visible results on the skin or joints.

To learn more about when to take collagen, visit our blog.

Recipes and tips

Add your collagen to a smoothie, fresh juice, latte coffee, or warm soup. Intermittent fasting enthusiasts can consume it during their eating window. The key is daily consistency.

Clinical results on skin, hair, and nails

Numerous clinical studies have demonstrated that hydrolyzed collagen:

• Increases skin elasticity by +12% in 8 weeks;

• Reduces wrinkle depth by up to -20%;

• Strengthens fragile nails by reducing breakage;

• Improves hair growth and shine.

Studies on joints and bones

Trials have shown that hydrolyzed collagen:

• Reduces joint pain in athletes and the elderly;

• Improves joint mobility ;

• Contributes to bone density, especially in postmenopausal women.

Limitations and perspectives of research

Although the results are promising, it is important to emphasize that effects may vary depending on age, lifestyle, and overall health status. Further research is needed to fully explore the potentials of hydrolyzed collagen.

Summary of benefits

Hydrolyzed collagen is a valuable ally for:

• Youthfulness and firmness of the skin;

• Strength of hair and nails;

• Joint comfort and bone health.

Its hydrolyzed form guarantees rapid absorption, optimal bioavailability, and targeted action on all connective tissues.

Final tips for effective supplementation

• Choose a quality hydrolyzed collagen, without additives;

• Maintain a regular daily dosage (min 2.5g);

• Follow a 3-month treatment, renewable as needed;

• Combine with a diet rich in vitamin C to stimulate endogenous synthesis.

449 To learn more, discover our dedicated article on when to take collagen to optimize its effectiveness.

Scientific studies

- Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation with specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014.

- Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a literature review. Curr Med Res Opin. 2006.